Using science to simplify life

Synectix Pharmaceutical Solutions Ltd constantly scans, analyses and identifies the need for change and improvement in existing particle processing and drug delivery systems, particularly for oral and parenteral dosage forms for low solubility, poorly bioavailable compounds. This leads to the creation and development of new technologies that provide value enrichment to our clients. Some unique technologies have already emerged out of this activity and are available to third parties for drug specific evaluation.

• SOLENT™ Array

Developed by the scientists and Synectix, the SOLENT™ (Solubility Enhancement Technology) Array is a rapid and low-cost liquid formulation screening platform designed to help identify high dose formulation options to support preclinical toxicity testing (parenteral) and oral bioavailability (PK) studies. Specifically focussed on low solubility, hydrophobic drug compounds, the process capitalises on laboratory semi-automation controlled through a sophisticated database approach to yield results quickly and cost-efficiently.
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• SOLENT-BIO™

Developed as an extension to the traditional SOLENT™ Array, SOLENT-BIO™ is a rapid and low-cost high-throughput formulation screening platform specifically designed for biomolecules (proteins and peptides) to identify liquid formulations suitable for sterile filtration and subsequent direct injection or freeze-drying.

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• PRORELEASE™

Our ProRelease™ amorphous solid dispersion (ASD) technology increases the oral bioavailability of poorly soluble drugs by enhancing the kinetic solubility and dissolution velocity in the biological fluid media. The resulting increase in solubility and exposure can lead to a reduction in dose variability and adverse reactions whilst providing a rapid onset of action leading to better patient compliance and favorable therapeutic outcome.

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• LENA™ NANOCEUTICS

The Lena™ nanoceutics system is a proven particle processing technology that can enhance the dispersion and deposition of hydrophobic actives by dramatically reducing particle size and increasing particulate surface area. The result is an aqueous dispersion of the drug substance that behaves like a solution and which can be processed into finished dosage forms for all routes of administration

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