expert analysis, not just data!

At Synectix, we offer a comprehensive menu of analytical chemistry services and techniques for profiling both drug substances and formulated products. Whether you have one sample or one hundred, we can quickly and cost effectively analyse your materials as well as perform cGMP Analytical Method Development and Limit Testing for polymorphs and other solid forms. Our founding scientists are recognised leaders in the field of solid-state characterisation of pharmaceutical materials, including advanced spectroscopic methods for polymorph determination and calorimetric techniques for amorphous content detection and quantification and rapid excipient incompatibility testing.

If you need significant Solid State Structural Characterisation, including Chemical Manufacturing Control (CMC) support, we can help. For drug substance characterisation, we offer complete solutions and development options, with each project specially designed around the needs of each indivual client. Below is a list of techniques available (x denotes cGMP analysis capability).

Structure Elucidation

• Solution and solid-state NMR spectroscopy
• IR spectroscopy (x)
• single crystal structure determination
• Mass spectrometry

Physical Characterization

• X-ray powder diffraction (XRPD), including variable temperature / humidity (x)
• Optical cross-polarisation hot-stage microscopy
• Differential scanning calorimetry (DSC), including fast-Scan and modulated methods (x)
• Thermogravimetry (TG) (x)
• Melting point determination
• Moisture sorption/desorption isotherms (water and organic vapours)
• Infrared (IR) spectroscopy (x)
• Raman confocal spectroscopy
• Solid-state nuclear magnetic resonance (NMR) spectroscopy
• Ultraviolet (UV)spectrum (x)
• Particle size distribution (wet dispersion and dry powder) (x)
• Surface area analysis (x)
• Scanning electron microscopy

Specialist Thermal Analysis and Calorimetry

• Isothermal gas perfusion microcalorimetry
• High-sensitivity step-isothermal calorimetry
• Project RHC (Rapid Heating Scanning Calorimetry)
• Multi-channel DSC (MC-DSC) • Photocalorimetry
• Microsolution calorimetry
• Powder-pocket dynamic mechanical analysis

Preformulation Data

• Polymorphic form determination
• Equilibrium solubility measurement
• pH solubility profiling
• pKa determination
• Log P
• Log D
• Amorphous content screening